PXD038508

PXD038508 is an original dataset announced via ProteomeXchange.

Title	Dynamic Data Independent Acquisition Mass Spectrometry with Real-Time Retrospective Alignment
Description	We report a data independent acquisition (DIA) strategy that dynamically adjusts the tandem mass spectrometry (MS/MS) windows during the chromatographic separation. The method focuses MS/MS acquisition on the most relevant mass range at each point in time – improving the quantitative sensitivity by increasing the time spent on each DIA window. We demonstrate an improved lower limit of quantification, on average, without sacrificing the number of peptides detected.
HostingRepository	PanoramaPublic
AnnounceDate	2023-09-18
AnnouncementXML	Submission_2023-09-18_21:39:56.437.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Lilian Heil
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	Carbamidomethyl; Label:13C(6)15N(2); Label:13C(6)15N(4)
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2022-12-01 18:52:26	ID requested
1	2022-12-02 10:48:13	announced
⏵ 2	2023-09-18 21:39:57	announced	: Added PubMed Id

Heil LR, Remes PM, Canterbury JD, Yip P, Barshop WD, Wu CC, MacCoss MJ, Dynamic Data-Independent Acquisition Mass Spectrometry with Real-Time Retrospective Alignment. Anal Chem, 95(32):11854-11858(2023) [pubmed]

submitter keyword: DIA, data independent acquisition

Michael MacCoss
contact affiliation	University of Washington
contact email	maccoss@uw.edu
lab head
Lilian Heil
contact affiliation	University of Washington
contact email	lheil2@uw.edu
dataset submitter

Panorama Public dataset URI