PXD038370

PXD038370 is an original dataset announced via ProteomeXchange.

Title	Dynamic monitoring of myeloma minimal residual disease with targeted mass spectrometry
Description	Serum samples from multiple myeloma (MM) patients are collected regularly for conventional tests to quantify the M-protein longitudinally. However, the limited sensitivity of conventional tests makes quantification of minimal residual disease (MRD) difficult. MRD can be quantified with highly sensitive molecular techniques on bone marrow, but bone marrow procedures are invasive and cannot be performed regularly. In this study, we introduce highly sensitive targeted mass spectrometry (MS-MRD) to quantify M-protein from patient serum. Therefore, we can follow each patient’s course of disease and dynamically measure MRD.
HostingRepository	PanoramaPublic
AnnounceDate	2023-02-27
AnnouncementXML	Submission_2023-02-27_13:40:33.908.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Somayya Noori
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	Carbamidomethyl; Label:13C(6)15N(2); Label:13C(6)15N(4)
Instrument	Orbitrap Exploris 120

Revision	Datetime	Status	ChangeLog Entry
0	2022-11-25 21:14:56	ID requested
⏵ 1	2023-02-27 13:40:34	announced

Noori S, Wijnands C, Langerhorst P, Bonifay V, Stingl C, Touzeau C, Corre J, Perrot A, Moreau P, Caillon H, Luider TM, Dejoie T, Jacobs JFM, van Duijn MM, Dynamic monitoring of myeloma minimal residual disease with targeted mass spectrometry. Blood Cancer J, 13(1):30(2023) [pubmed]

submitter keyword: multiple myeloma, minimal residual disease, M-protein, clonotypic peptides, targeted mass spectrometry

Martijn van Duijn
contact affiliation	Erasmus University Medical Center Rotterdam, The Netherlands
contact email	m.m.vanduijn@erasmusmc.nl
lab head
Somayya Noori
contact affiliation	Erasmus University Medical Center Rotterdam, The Netherlands
contact email	s.noori@erasmusmc.nl
dataset submitter

Panorama Public dataset URI