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PXD038370

PXD038370 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDynamic monitoring of myeloma minimal residual disease with targeted mass spectrometry
DescriptionSerum samples from multiple myeloma (MM) patients are collected regularly for conventional tests to quantify the M-protein longitudinally. However, the limited sensitivity of conventional tests makes quantification of minimal residual disease (MRD) difficult. MRD can be quantified with highly sensitive molecular techniques on bone marrow, but bone marrow procedures are invasive and cannot be performed regularly. In this study, we introduce highly sensitive targeted mass spectrometry (MS-MRD) to quantify M-protein from patient serum. Therefore, we can follow each patient’s course of disease and dynamically measure MRD.
HostingRepositoryPanoramaPublic
AnnounceDate2023-02-27
AnnouncementXMLSubmission_2023-02-27_13:40:33.908.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterSomayya Noori
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListCarbamidomethyl; Label:13C(6)15N(2); Label:13C(6)15N(4)
InstrumentOrbitrap Exploris 120
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-11-25 21:14:56ID requested
12023-02-27 13:40:34announced
Publication List
Noori S, Wijnands C, Langerhorst P, Bonifay V, Stingl C, Touzeau C, Corre J, Perrot A, Moreau P, Caillon H, Luider TM, Dejoie T, Jacobs JFM, van Duijn MM, Dynamic monitoring of myeloma minimal residual disease with targeted mass spectrometry. Blood Cancer J, 13(1):30(2023) [pubmed]
Keyword List
submitter keyword: multiple myeloma, minimal residual disease, M-protein, clonotypic peptides, targeted mass spectrometry
Contact List
Martijn van Duijn
contact affiliationErasmus University Medical Center Rotterdam, The Netherlands
contact emailm.m.vanduijn@erasmusmc.nl
lab head
Somayya Noori
contact affiliationErasmus University Medical Center Rotterdam, The Netherlands
contact emails.noori@erasmusmc.nl
dataset submitter
Full Dataset Link List
Panorama Public dataset URI