To understand how ADAR1 controls genome stability, affinity purification and mass spectrometry were employed to identify the interactomes of ADAR1 with cellular extracts from HeLa cells stably expressing FLAG-ADAR1.Mass spectrometry analysis of FLAG-ADAR1 associated proteins. The differential protein bands of the immunoprecipitates from cellular extracts of HeLa cells were retrieved from silver stained SDS-PAGE, digested with trypsin and analyzed by mass spectrometry.