PXD037744

PXD037744 is an original dataset announced via ProteomeXchange.

Title	Lactylation contributes to colorectal carcinogenesis
Description	To reveal the lactylated proteins in CRC, we analyzed the lactyl-proteome from seven paired biopsies from CRC patients by using mass spectrometry analysis (LC-MS/MS). Meanwhile, we used LC-MS to identify Kla and Kac substrates upon HCT116 cells.
HostingRepository	iProX
AnnounceDate	2022-10-27
AnnouncementXML	Submission_2025-06-30_01:00:07.093.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bingteng Xie
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	acetylated residue
Instrument	Orbitrap Fusion Lumos; timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-26 23:21:17	ID requested
⏵ 1	2025-06-30 01:00:07	announced

Xie B, Zhang M, Li J, Cui J, Zhang P, Liu F, Wu Y, Deng W, Ma J, Li X, Pan B, Zhang B, Zhang H, Luo A, Xu Y, Li M, Pu Y, KAT8-catalyzed lactylation promotes eEF1A2-mediated protein synthesis and colorectal carcinogenesis. Proc Natl Acad Sci U S A, 121(8):e2314128121(2024) [pubmed]

submitter keyword: lactylation, colorectal carcinogenesis

Bingteng Xie
contact affiliation	Beijing Institute of Technology
contact email	xiebingteng@bit.edu.cn
lab head
Bingteng Xie
contact affiliation	Beijing Institute of Technology
contact email	xiebingteng@bit.edu.cn
dataset submitter

iProX dataset URI