PXD037003

PXD037003 is an original dataset announced via ProteomeXchange.

Title	Proteome of R1441C and G2019S LRRK2 knock in mice after striatal motor learning task
Description	LRRK2 mutations are associated with both familial and sporadic forms of Parkinson’s disease (PD). Convergent evidence suggests that LRRK2 plays critical roles in regulating striatal function. Here, by using knock-in mouse lines that express the two most common LRRK2 pathogenic mutations—G2019S and R1441C—we investigated how pathogenic LRRK2 mutations altered striatal physiology. To identify the signaling pathways that underlie the motor learning deficits, specifically in the RC mice we performed six-plex tandem mass tag (TMT) quantitative mass spectrometry (MS) to compare the protein expression of either RC or GS and WT mice following the five days of the rotarod test.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:09:36.568.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Renu Goel
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-09-25 15:26:21	ID requested
1	2022-12-14 19:13:18	announced
⏵ 2	2023-11-14 08:09:40	announced	2023-11-14: Updated project metadata.

Xenias HS, Chen C, Kang S, Cherian S, Situ X, Shanmugasundaram B, Liu G, Scesa G, Savio Chan C, Parisiadou L, R1441C and G2019S LRRK2 knockin mice have distinct striatal molecular, physiological, and behavioral alterations. Commun Biol, 5(1):1211(2022) [pubmed]

submitter keyword: mouse, brain, striatum, LC-MS/MS

Loukia Parisiadou
contact affiliation	Department of Pharmacology, Feinberg School of Medicine, Northwestern University
contact email	Loukia.parisidaou@northwestern.edu
lab head
Renu Goel
contact affiliation	Northwestern University
contact email	drrenugoel@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/12/PXD037003

PRIDE project URI

• PRIDE
  1. PXD037003
     1. Label: PRIDE project
     2. Name: Proteome of R1441C and G2019S LRRK2 knock in mice after striatal motor learning task