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PXD034882 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTandem Mass Tag-Based Quantitative Proteomic Profiling Identifies Novel Serum Biomarkers of Drug-Induced Liver Injury in Humans
DescriptionDiagnosis of drug-induced liver injury (DILI) and its distinction from other liver diseases are significant challenges in drug development and clinical practice. In this study we identify, confirm, and replicate the biomarker performance characteristics of candidate proteins in a cohort of patients with DILI at onset (DO; n = 133) and follow-up (DF; n = 120), acute non-DILI at onset (NDO; n = 63) and follow-up (NDF; n = 42), and healthy volunteers (HV; n = 104). Area under the receiver operating characteristic curve (AUC) for cytoplasmic aconitate hydratase; argininosuccinate synthase; carbamoylphosphate synthase, fumarylacetoacetase; fructose-1,6-bisphosphatase 1 (FBP1) across cohorts achieves near complete separation (range: 0.94 - 0.99) of DO and HV. In addition, we show that FBP1 alone or in combination with glutathione S-transferase A1 and leukocyte cell derived chemotaxin 2 could potentially assist in clinicla diagnosis by distinguishing NDO from DO (AUC range: 0.65 – 0.78), but further technical and clinical validation of these candidate biomarkers is needed.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterJoel Federspiel
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListLabel:13C(6)15N(2); Label:13C(6)15N(4)
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-06-25 23:13:10ID requested
12023-01-26 11:28:31announced
22024-01-04 11:58:18announced: Added PubMed Id
Publication List
Ravindra KC, Vaidya VS, Wang Z, Federspiel JD, Virgen-Slane R, Everley RA, Grove JI, Stephens C, Ocana MF, Robles-D, í, az M, Isabel Lucena M, Andrade RJ, Atallah E, Gerbes AL, Weber S, Cortez-Pinto H, Fowell AJ, Hussaini H, Bjornsson ES, Patel J, Stirnimann G, Verma S, Elsharkawy AM, Griffiths WJH, Hyde C, Dear JW, Aithal GP, Ramaiah SK, Tandem mass tag-based quantitative proteomic profiling identifies candidate serum biomarkers of drug-induced liver injury in humans. Nat Commun, 14(1):1215(2023) [pubmed]
Keyword List
submitter keyword: DILI, Biomarker, Liver Disease
Contact List
Mireia Fernandez Ocana
contact affiliationPfizer Inc.
contact emailmireia.fernandezocana@pfizer.com
lab head
Joel Federspiel
contact affiliationPfizer, Inc.
contact emailjoel.federspiel@pfizer.com
dataset submitter
Full Dataset Link List
Panorama Public dataset URI