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Two simulated nerve injury models in the rat tibial nerve were compared: the nerve was either cut (denervated, DN group) or crushed but with the nerve sheath intact (re-innervated, RN group). The control group had a preserved and intact tibial nerve. As the high expression of Myh3, Postn, Col6a1 and Cfi (nerve growth factors), the RN group demonstrated superior re-innervation as well. Both differentially expressed genes (DEGs) and proteins (DEPs) were enriched in the PPAR signaling pathway, as well as the energy metabolism.