Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Continuous renal replacement therapy (CRRT) is regarded as an adjuvant therapy for critically ill, which removes excess fluids and clear uremic toxins, endotoxins, proteins, and inflammatory mediators efficiently. In patients with sepsis, CRRT has the advantages of maintaining hemodynamic stability, accurate fluid control, and steady acid-base and electrolyte correction. 2020 “Surviving Sepsis Campaign (SSC) international guidelines” for children suggested that CRRT should be considered in hemodynamically unstable septic patients for promoting management of fluid balance and acute kidney injury (AKI).Blood levels of cytokines (such as interleukin-8 [IL-8], tumor necrosis factor -α [TNF-α], IL-10, and IL-6) and endotoxins are often elevated in patients with sepsis. CRRT removing endotoxins and cytokines from septic patients is associated with improved patient outcomes. Our previous multicenter study indicated th