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PXD032718

PXD032718 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleARL6IP1 is an interacting partner of the ER-phagy receptor FAM134B
DescriptionER-resident membrane-shaping proteins with central reticulon homology domains (RHDs) have been associated with neurodegenerative disorders such as ARL6IP1 and FAM134B.Mutations in ARL6IP1 cause SPG61, a neurodegenerative disorder characterized by progressive leg spasticity (hereditary spastic paraplegia/HSP) in combination with loss of sensory and pain perception, thus reproducing typical symptoms of HSAN {Kurth, 2009 #8;Novarino, 2014 #28;Nizon, 2018 #162}.Our objetive was to analyse FAM134B-ARL6IP1 protein protein interactionS to underlying mechanisms, required for effective ER-remodelling and ER-phagy.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:48:45.771.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAdriana Covarrubias-Pinto
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-03-23 02:56:52ID requested
12023-06-19 06:44:46announced
22023-11-14 09:01:27announced2023-11-14: Updated project metadata.
32024-10-22 05:48:47announced2024-10-22: Updated project metadata.
Publication List
10.1038/s41586-023-06090-9;
Foronda H, Fu Y, Covarrubias-Pinto A, Bocker HT, Gonz, á, lez A, Seemann E, Franzka P, Bock A, Bhaskara RM, Liebmann L, Hoffmann ME, Katona I, Koch N, Weis J, Kurth I, Gleeson JG, Reggiori F, Hummer G, Kessels MM, Qualmann B, Mari M, Diki, ć I, H, ü, bner CA, Heteromeric clusters of ubiquitinated ER-shaping proteins drive ER-phagy. Nature, 618(7964):402-410(2023) [pubmed]
Keyword List
submitter keyword: HA FAM134B, ARL6IP1
Contact List
Ivan Dikic
contact affiliationInstitute of Biochemistry II, Goethe University School of Medicine, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany
contact emaildikic@biochem2.uni-frankfurt.de
lab head
Adriana Covarrubias-Pinto
contact affiliationGoethe University
contact emailCovarrubiasPinto@med.uni-frankfurt.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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