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PXD031697 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAbsolute Protein Quantitation of the Mouse Macrophage Toll-Like Receptor and Chemotaxis Pathways
DescriptionThe Toll-like receptor and chemotaxis pathways are key components of the innate immune system. Computational modeling and simulation at the molecular interaction level can be used to study complex biological pathways, but protein concentration values must be input as model parameters. In this investigation, targeted mass spectrometry assays were developed and used to measure the absolute abundance (copies/cell) of proteins of the mouse macrophage Toll-like receptor 4 (TLR4) and chemotaxis pathways. The data produced by this investigation can be used for pathway modeling and simulation, as well as for other systems biology research.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportsupported by repository but incomplete data and/or metadata
PrimarySubmitterNathan Manes
SpeciesList scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationListDeamidated; Acetyl; Phospho; Carbamidomethyl; Gln->pyro-Glu; Oxidation; Label:13C(6)15N(4); Label:13C(6)15N(2)
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-02-16 00:11:05ID requested
12022-08-01 14:11:11announced
22022-08-15 10:28:11announced: Added PubMed Id
Publication List
Manes NP, Calzola JM, Kaplan PR, Fraser IDC, Germain RN, Meier-Schellersheim M, Nita-Lazar A, Absolute protein quantitation of the mouse macrophage Toll-like receptor and chemotaxis pathways. Sci Data, 9(1):491(2022) [pubmed]
Keyword List
submitter keyword: macrophage, chemotaxis pathway, Toll-like receptor pathway, parallel reaction monitoring
Contact List
Aleksandra Nita-Lazar
contact affiliationNational Institutes of Health, USA
contact emailnitalazarau@niaid.nih.gov
lab head
Nathan Manes
contact affiliationNational Institutes of Health, USA
contact emailnathan.manes@nih.gov
dataset submitter
Full Dataset Link List
Panorama Public dataset URI