PXD031697
PXD031697 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Absolute Protein Quantitation of the Mouse Macrophage Toll-Like Receptor and Chemotaxis Pathways |
| Description | The Toll-like receptor and chemotaxis pathways are key components of the innate immune system. Computational modeling and simulation at the molecular interaction level can be used to study complex biological pathways, but protein concentration values must be input as model parameters. In this investigation, targeted mass spectrometry assays were developed and used to measure the absolute abundance (copies/cell) of proteins of the mouse macrophage Toll-like receptor 4 (TLR4) and chemotaxis pathways. The data produced by this investigation can be used for pathway modeling and simulation, as well as for other systems biology research. |
| HostingRepository | PanoramaPublic |
| AnnounceDate | 2022-08-15 |
| AnnouncementXML | Submission_2022-08-15_10:28:11.084.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | supported by repository but incomplete data and/or metadata |
| PrimarySubmitter | Nathan Manes |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | Deamidated; Acetyl; Phospho; Carbamidomethyl; Gln->pyro-Glu; Oxidation; Label:13C(6)15N(4); Label:13C(6)15N(2) |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-02-16 00:11:05 | ID requested | |
| 1 | 2022-08-01 14:11:11 | announced | |
| ⏵ 2 | 2022-08-15 10:28:11 | announced | : Added PubMed Id |
Publication List
| Manes NP, Calzola JM, Kaplan PR, Fraser IDC, Germain RN, Meier-Schellersheim M, Nita-Lazar A, Absolute protein quantitation of the mouse macrophage Toll-like receptor and chemotaxis pathways. Sci Data, 9(1):491(2022) [pubmed] |
Keyword List
| submitter keyword: macrophage, chemotaxis pathway, Toll-like receptor pathway, parallel reaction monitoring |
Contact List
| Aleksandra Nita-Lazar | |
|---|---|
| contact affiliation | National Institutes of Health, USA |
| contact email | nitalazarau@niaid.nih.gov |
| lab head | |
| Nathan Manes | |
| contact affiliation | National Institutes of Health, USA |
| contact email | nathan.manes@nih.gov |
| dataset submitter | |
Full Dataset Link List
| Panorama Public dataset URI |
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