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PXD030492 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDynamics of allosteric regulation of the phospholipase C-gamma isoform
Descriptionwe used hydrogen deuterium exchange masss spec (HDX-MS) to define the exchange kinetics of PLC-y1 as it interacts with the kinase domain of FGFR1, and liposomes containing PIP2, in order to understand how PLC-y isozymes operate at membranes. We show that the binding of FGFR1k to PLC-y1 increases deuterium incorporation within the interface between the regulatory domains and the catalytic core. Importantly, the addition of liposomes further increase deuterium exchange within the same region.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJohn Burke
SpeciesList scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationListNo PTMs are included in the dataset
Instrumentimpact HD
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-12-17 12:57:46ID requested
12022-06-14 14:01:25announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: PLC, HDXMS
Contact List
Dr John E Burke
contact affiliationUniversity of Victoria
contact emailjeburke@uvic.ca
lab head
John Burke
contact affiliationUniversity of Victoria
contact emailjeburke@uvic.ca
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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