Update publication information. To analyze the mechanisms underlying DNA-PKcs deletion-mediated renoprotection in an unbiased fashion, we performed proteomic analysis using label free technology to obtain the protein expression profiles in control and DNA-PKcs-deficient mice subjected to septic AKI. 631 proteins were altered by DNA-PKcs deletion during septic AKI (log2FC>1.5), among which 274 proteins reached statistical difference. An expression volcano map of the differentially expressed proteins showed that 153 proteins were upregulated and 121 were downregulated. Kyoto Encyclopedia of Genes and Genome (KEGG) analysis of the 274 proteins showed that the apoptosis pathway was the most downregulated upon DNA-PKcs deletion during septic AKI. Gene Ontology (GO) Cellular Component Enrichment Analysis demonstrated that 101 of the 274 proteins were enriched to mitochondria