PXD029761

PXD029761 is an original dataset announced via ProteomeXchange.

Title	Expanding redox-based ligandability in the human cysteinome
Description	Cysteine in proteins can perform diverse functions owing to its intrinsically high nucleophilicity. The development of cysteine-specific electrophiles, in combination with state-of-the-art chemoproteomics, have greatly expanded the ligandable and druggable space in the human proteome. In addition, protein cysteines are subjected to diverse redox chemistry in cells. Oxidation of nucleophilic cysteinyl thiols to amphoteric sulfenic acids can abolish their reactivity toward electrophiles, yet chemical tools to modulate such redox functionality of cysteine are underdeveloped. Here we report a large-scale quantitative analysis of nucleophilic fragment compounds target-profiled against the human sulfenylome .
HostingRepository	iProX
AnnounceDate	2021-11-16
AnnouncementXML	Submission_2021-11-15_22:48:23.759.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ling Fu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2021-11-15 22:47:51	ID requested
⏵ 1	2021-11-15 22:48:24	announced

Dataset with its publication pending

submitter keyword: chemoproteomics，nucleophilic fragment，sulfenylome

Jing Yang
contact affiliation	Beijing Proteome Research Center
contact email	yangjing54@hotmail.com
lab head
Ling Fu
contact affiliation	Beijing Proteome Research Center
contact email	flsmt@163.con
dataset submitter

iProX dataset URI