Mesenchymal cells in human lung are heterogneous and can display a large variation in both functional properties and spatial localization. However it remain unclear to witch extent these observed cell population represent different cell types or just different cellular states. Furthermore, the lack of specific markers has hampered the progress within the field. In this study we aimed to investigate the proteome of mesenchymal cells derived from human lung as a starting point to learn more about mesenchymal subsets and identify novel markers.