Update publication information. Follicular atresia is an important factor affecting reproductive performance. In birds, less than 5% of follicles could complete their development process and mature ovulation, while the other 95% become atretic follicles and eventually degraded3. Yangzhou geese are famous for their high egg production, however, the average number of eggs per goose is 40-80 and the peak laying rate is 40%-50%12. As an important meat source of poultry, the low egg production of goose has seriously affected the production cost and industrialization development. How to avoid follicular atresia and promote its normal development could help to improve egg production. Therefore, understanding the mechanism of follicular atresia in geese is of great significance for improving egg production.Isobaric tags for relative and absolute quantification (iTRAQ) labeling coupled to liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used to quantitatively identify differentially expressed proteins (DEPs) between normal and atretic follicles.