We have analyzed by label free mass spectrometry the whole cells and secreted extracellular vesicles (EVs) proteomes of two different molecular subtypes of DLBCL, germinal center B cell (GCB subtype) and activated B cell (ABC subtype). Cell line: OCI-Ly3 (ABC) O3_2.raw O3_1.raw O2_2.raw O2_1.raw O1_2.raw O1_1.raw Cell line: HT (GCB) H4_2.raw H4_1.raw H3_2.raw H3_1.raw H2_2.raw H2_1.raw H1_2.raw H1_1.raw EVs OCI-Ly3 eO2_2.raw eO2_1.raw eO2.raw eO1_2.raw eO1_1.raw eO1.raw EVs HT eH2_2.raw eH2_1.raw eH2.raw eH1_2.raw eH1_1.raw eH1.raw EVs cell line RIVA: D3_2.raw D3_1.raw D2_2.raw D2_1.raw D1_2.raw D1_1.raw EVs cell line DB: C3_2.raw C3_1.raw C2_2.raw C2_1.raw C1_2.raw C1_1.raw Cell line: RIVA (ABC) B3_2.raw B3_1.raw B2_2.raw B2_1.raw B1_2.raw B1_1.raw Cell line: DB (GCB) A3_2.raw A3_1.raw A2_2.raw A2_1.raw A1_2.raw A1_1.raw