To outline the temporal changes of long COVID, we profiled serum proteomes (dataset SP2) and urine proteomes (dataset UP2). The SP2 were measured for 37 patients during the disease (T1), the convalescence (T2), and at the 1-year revisit (T3); the UP2 were measured for 28 patients during the disease (T1) and at the revisit (T3). An equivalent number of healthy controls were added to each dataset. A validation cohort of 15 patients were further recruited during day 397 (386-487) to verify the unity of the prioritized serum proteins in predicting long COVID after one year.