PXD025484

PXD025484 is an original dataset announced via ProteomeXchange.

Title	Peripheral blood proteomic signature of newly diagnosed prostate cancer
Description	Prostate cancer (PCa) is the most common malignant tumour, with high incidence rates and heterogeneity in men around the world. It is becoming an increasing burden on the health care system due to lack of tests for precise detection of disease, risk assessment and response to treatments. We used SWATH-MS as a discovery proteomics tool to identify markers in the serum of newly diagnosed PCa patients and healthy controls to facilitate the improved diagnosis. Furthermore, identification and expression of proteins was also determined in patients undergone radiotherapy and prostatectomy for monitoring of the clinical response to respective treatment options. Thus, this study provides the basis for a proteomic signature to improve diagnostics of patients with localised prostate cancer.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:43:43.090.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	AMMARA MUAZZAM
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	TripleTOF 6600

Revision	Datetime	Status	ChangeLog Entry
0	2021-04-20 02:16:09	ID requested
1	2023-03-11 10:26:14	announced
2	2023-11-14 08:43:42	announced	2023-11-14: Updated project metadata.
⏵ 3	2024-10-22 05:43:44	announced	2024-10-22: Updated project metadata.

10.3390/cancers15041051;

Muazzam A, Spick M, Cexus ONF, Geary B, Azhar F, Pandha H, Michael A, Reed R, Lennon S, Gethings LA, Plumb RS, Whetton AD, Geifman N, Townsend PA, A Novel Blood Proteomic Signature for Prostate Cancer. Cancers (Basel), 15(4):(2023) [pubmed]

submitter keyword: proteomics, clinical onset, SWATH-MS, biomarkers,Prostate cancer

Anthony Whetton
contact affiliation	Stoller Biomarker Discovery Center, University of Manchester, Manchester, England
contact email	tony.whetton@manchester.ac.uk
lab head
AMMARA MUAZZAM
contact affiliation	University of Manchester
contact email	ammara.muazzam@postgrad.manchester.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD025484

PRIDE project URI

• PRIDE
  1. PXD025484
     1. Label: PRIDE project
     2. Name: Peripheral blood proteomic signature of newly diagnosed prostate cancer