The venom proteomes of three medically important Nigerian Elapidae snakes Naja haje, Naja katiensis and Naja nigricollis was studied using Hydrophilic Interaction Liquid Chromatography (HILIC) coupled with LC-MS/MS analysis. Peptides/Proteins were identified and characterised using the SEQUEST and X!Tandem algorithms incorporated on to the Scaffold proteome software version 4.10.0. The Nigerian elapid species studied displayed about 70% similarity in composition of their venoms.