Update information. In this study, we investigated the effect of water activity on transcriptome and proteome of Aspergillus flavus spore germination.we investigated the most important protein in PPI network in proteome, the S-adenosylmethionine-dependent methyltransferase superfamily domain-containing protein. Studies on S-adenosylmethionine (SAM)-dependent methyltransferases showed that it is crucial in cell signaling, metabolism and epigenetic programming