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PXD023711 is an original dataset announced via ProteomeXchange.

Dataset Summary
Titleα-Catenin Levels Determine Direction of YAP/TAZ Response to Autophagy Perturbation
DescriptionThe factors regulating cellular identity are critical for understanding the transition from health to disease and responses to therapies. Cell identity is generally assigned based on static phenotypes, like “omics” profiles. However, how such static features translate into dynamic responses to perturbations that determine cellular function is often unclear. We found that autophagy perturbation in different cell types can have opposite responses in growth-promoting oncogenic YAP/TAZ transcriptional signalling. These apparently contradictory responses can be resolved by a feedback loop where autophagy negatively regulates the levels of α-catenins LC3-interacting proteins, which inhibit YAP/TAZ, which, in turn, positively regulate autophagy. High basal levels of α-catenins enable autophagy induction to positively regulate YAP/TAZ, while low α-catenins cause YAP/TAZ activation upon autophagy inhibition. These data reveal how feedback loops enable post-transcriptional determination of cell identity and how levels of a single intermediary protein can dictate the direction of response to external or internal perturbations.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJack Houghton
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF; Q Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-01-20 08:56:19ID requested
12021-03-18 22:59:40announced
Publication List
Pavel M, Park SJ, Frake RA, Son SM, Manni MM, Bento CF, Renna M, Ricketts T, Menzies FM, Tanasa R, Rubinsztein DC, -Catenin levels determine direction of YAP/TAZ response to autophagy perturbation. Nat Commun, 12(1):1703(2021) [pubmed]
Keyword List
submitter keyword: α-Catenin, autophagy, YAP/TAZ
Contact List
David Rubinsztein
contact affiliationCambridge Insitute for Medical Resarch, University of Cambridge
contact emaildcr1000@cam.ac.uk
lab head
Jack Houghton
contact affiliationUniversity of Cambridge
contact emailjwh65@cam.ac.uk
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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