Ribosome biogenesis is an essential process within cells that requires integration of extracellular cues such as metabolic states through signaling with transcriptional regulation and maintenance of accessible chromatin at the ribosomal DNA. Here, we demonstrate that the recently identified histone modification, methylation of H2AQ105 is an integral part of a dynamic chromatin network at the rDNA locus. Its deposition depends on a functional mTor signaling pathway and acetylation of histone H3 at position K56, thus integrating signals from cell cycle and proliferative states. Furthermore, we identify a first epigenetic reader of this modification. The ribonucleoprotein Nhp2 specifically recognizes methylation H2AQ105me. Based on functional and proteomic data we suggest that Nhp2 functions as an adapter to bridge chromatin and components of the small subunit processome and might help to efficiently coordinate transcription of rRNA with its post-transcriptional processing.