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PXD023347 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleUSP36-mediated deubiquitination of DOCK4 contributes to the diabetic renal tubular epithelial cell injury via Wnt/β-catenin signaling pathway
DescriptionDiabetic kidney disease (DKD) has become the leading cause of end-stage renal diseases, but the efficacy of current treatment remains unsatisfactory. The pathogenesis of DKD needs a more in-depth research. Ubiquitin specific proteases 36 (USP36), a member of deubiquitinating enzymes family, has aroused wide concerns for its role in deubiquitinating and stabilizing target proteins. Nevertheless, the role of USP36 in diabetes has never been reported yet. Herein, we identified an increased expression of USP36 both in vitro and in vivo in diabetic renal tubular epithelial cells (TECs), and its overexpression is related to the enhanced epithelial-to-mesenchymal transition (EMT). Further investigation into the mechanisms proved that USP36 could directly bind to and mediate the deubiquitination of dedicator of cytokinesis 4 (DOCK4), a guanine nucleotide exchange factor (GEF) that could activate Wnt/β-catenin signaling pathway and induce EMT. Our study revealed a new mechanism that USP36 participates in the pathogenesis of DKD, and provided potential intervening targets accordingly.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSuwei Zhu
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-01-04 00:19:45ID requested
12021-09-09 15:45:05announced
Publication List
Zhu S, Hou S, Lu Y, Sheng W, Cui Z, Dong T, Feng H, Wan Q, -Catenin Signaling Pathway. Front Cell Dev Biol, 9():638477(2021) [pubmed]
Keyword List
submitter keyword: ubiquitin specific proteases 36, dedicator of cytokinesis 4, Wnt/β-catenin, diabetic kidney disease, deubiquitination, epithelial-to-mesenchymal transition
Contact List
Suwei Zhu
contact affiliationShandong University
contact email1446245184@qq.com
lab head
Suwei Zhu
contact affiliationShandong Uniersity
contact emailzhangzheyu@aksomics.com
dataset submitter
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Dataset FTP location
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