Kaempferitrin is extracted in significantly high quantities from the leaves of Cinnamomum osmophloeum, which belongs to the genus Cinnamomum, the same genus many antidiabetic herbal remedy in Chinese medicine. Oral administration of kaempferitrin reduces blood sugar in alloxan-induced diabetic rats. In this project, we studied the differential expression profile with proteomic approach using the liver cancer cell line hepG2, as liver cells were responsible for the regulation of lipid generation systemically.