PXD021853

PXD021853 is an original dataset announced via ProteomeXchange.

Title	Whole Lung Proteome in N. brasiliensis Infection in IL-13 deficient mice.
Description	IL-13 plays a key role during protective type 2 immune responses at mucosal sites, such as during infection with nematodes. However, dysregulation of IL-13 can also contribute to the pathogenesis of allergic and fibrotic diseases. Matrix remodelling is an important component of repair processes in the lung but is also a hallmark of chronic diseases such as asthma. Since IL-13 shares receptors and signalling pathways with IL-4, disentangling the relative contributions of these two type 2 cytokines has been challenging. Additionally, little is known about the singular role of IL-13 in more acute settings of tissue injury/repair and whether IL-13 regulates remodelling of the extracellular matrix following tissue injury. In this study, we used Nippostrongylus brasiliensis infection as model of acute lung tissue damage and repair by comparing responses between WT and IL-13-deficient mice, in which IL-4 signalling is intact.
HostingRepository	PRIDE
AnnounceDate	2021-06-11
AnnouncementXML	Submission_2021-06-10_22:03:05.172.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	James Parkinson
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-10-05 22:53:55	ID requested
⏵ 1	2021-06-10 22:03:05	announced

Dataset with its publication pending

submitter keyword: Mouse, Lung, IL-13, Helminth, Parasite

Prof. Judi Allen
contact affiliation	Faculty of Biology Medicine and Health, Wellcome Trust Centre for Cell-Matrix Research, Manchester Centre University of Manchester, United Kingdom
contact email	judi.allen@manchester.ac.uk
lab head
James Parkinson
contact affiliation	University of Manchester
contact email	james.parkinson@manchester.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD021853
     1. Label: PRIDE project
     2. Name: Whole Lung Proteome in N. brasiliensis Infection in IL-13 deficient mice.