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PXD021494 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleNew antiviral small molecule inhibitors disturb interactions between cellular HSP70 and virus proteins
DescriptionRNA virus outbreaks such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), Ebola virus (EBOV) and Zika virus (ZIKV) causing worldwide health emergencies have highlighted the urgent need of new antiviral strategies. Upon outbreaks with new, unmet viruses where knowledge of virus biology is limited, targeting host cell pathways supporting viral replication is an attractive approach for development of antiviral compounds. Here, we present a strategy to identify novel host-targeted small molecule inhibitors using image-based phenotypic antiviral assay followed by characterization of structure-activity-relationship, mechanism-of-action and molecular targets of the novel antiviral compound using thermal proteome profiling.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterRozbeh Jafari
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF; Q Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-09-15 09:31:33ID requested
12021-01-04 07:31:27announced
Publication List
Tampere M, Pettke A, Salata C, Wallner O, Koolmeister T, Cazares-K, ö, rner A, Visnes T, Hesselman MC, Kunold E, Wiita E, Kalder, é, n C, Lightowler M, Jemth AS, Lehti, ö J, Rosenquist Å, Warpman-Berglund U, Helleday T, Mirazimi A, Jafari R, Puumalainen MR, Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses. Viruses, 12(12):(2020) [pubmed]
Keyword List
submitter keyword: LC-MSMS, TPP, 2D-TPP, antiviral compound, virus proteins
Contact List
Rozbeh Jafari
contact affiliationDepartment of Oncology-Pathology (OnkPat) (PI)
contact emailrozbeh.jafari@ki.se
lab head
Rozbeh Jafari
contact affiliationKarolinska Institutet
contact emailrozbeh.jafari@ki.se
dataset submitter
Full Dataset Link List
Dataset FTP location
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