The nutrition contents of breastmilk can transfer into the blood of neonates, directly participating in neonatal immune response. The alternations of the components of breastmilk under the context of viral infection not only reflect the physiological changes in mothers but also affect neonatal immunity and metabolism via breastfeeding. There has been no report to demonstrate the changes of bioactive components in breastmilk of puerperant women with COVID-19. Thereby, we attempted to answer the important questions whether breastmilk production is affected by COVID-19 and whether breastfeeding is still a safe or recommended operation for puerperant women with COVID-19.