PXD021018 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Quantitative LC-MS/MS Proteomics of human brain microvessels |
Description | We report label-free quantification of xenobiotic metabolizing enzymes (XME), transporters, redox enzymes, proteases, nucleases and tight junction proteins in 22 human brain microvessel samples. More than 3500 proteins were identified and quantified. These data can be used in physiologically based pharmacokinetic models to predict drug disposition in the brain and permitting dose adjustment (precision dosing) in special populations of patients, such as those with dementia. |
HostingRepository | PRIDE |
AnnounceDate | 2021-09-09 |
AnnouncementXML | Submission_2021-09-09_03:21:55.163.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Zubida Al-Majdoub |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-08-19 23:59:12 | ID requested | |
⏵ 1 | 2021-09-09 03:21:56 | announced | |
Publication List
Al-Majdoub ZM, Achour B, Couto N, Howard M, Elmorsi Y, Scotcher D, Alrubia S, El-Khateeb E, Vasilogianni AM, Alohali N, Neuhoff S, Schmitt L, Rostami-Hodjegan A, Barber J, Mass spectrometry-based abundance atlas of ABC transporters in human liver, gut, kidney, brain and skin. FEBS Lett, 594(23):4134-4150(2020) [pubmed] |
Keyword List
submitter keyword: Human, brains, LC-MS/MS, quantitative proteomics |
Contact List
Jill Barber |
contact affiliation | Centre for Applied Pharmacokinetic Research, School of Health Sciences, The University of Manchester |
contact email | Jill.barber@manchester.ac.uk |
lab head | |
Zubida Al-Majdoub |
contact affiliation | The University of Manchester Centre for Applied Pharmacokinetic Research Division of Pharmacy and Optometry School of Health Sciences Oxford Road Stopford Building Room 3.32 M13 9PT |
contact email | Zubida.Al-Majdoub@manchester.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD021018 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD021018
- Label: PRIDE project
- Name: Quantitative LC-MS/MS Proteomics of human brain microvessels