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PXD021018

PXD021018 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleQuantitative LC-MS/MS Proteomics of human brain microvessels
DescriptionWe report label-free quantification of xenobiotic metabolizing enzymes (XME), transporters, redox enzymes, proteases, nucleases and tight junction proteins in 22 human brain microvessel samples. More than 3500 proteins were identified and quantified. These data can be used in physiologically based pharmacokinetic models to predict drug disposition in the brain and permitting dose adjustment (precision dosing) in special populations of patients, such as those with dementia.
HostingRepositoryPRIDE
AnnounceDate2021-09-09
AnnouncementXMLSubmission_2021-09-09_03:21:55.163.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterZubida Al-Majdoub
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-08-19 23:59:12ID requested
12021-09-09 03:21:56announced
Publication List
Al-Majdoub ZM, Achour B, Couto N, Howard M, Elmorsi Y, Scotcher D, Alrubia S, El-Khateeb E, Vasilogianni AM, Alohali N, Neuhoff S, Schmitt L, Rostami-Hodjegan A, Barber J, Mass spectrometry-based abundance atlas of ABC transporters in human liver, gut, kidney, brain and skin. FEBS Lett, 594(23):4134-4150(2020) [pubmed]
Keyword List
submitter keyword: Human, brains, LC-MS/MS, quantitative proteomics
Contact List
Jill Barber
contact affiliationCentre for Applied Pharmacokinetic Research, School of Health Sciences, The University of Manchester
contact emailJill.barber@manchester.ac.uk
lab head
Zubida Al-Majdoub
contact affiliationThe University of Manchester Centre for Applied Pharmacokinetic Research Division of Pharmacy and Optometry School of Health Sciences Oxford Road Stopford Building Room 3.32 M13 9PT
contact emailZubida.Al-Majdoub@manchester.ac.uk
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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