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<Cv fullName="PSI-MS" id="MS" uri="http://psidev.cvs.sourceforge.net/viewvc/*checkout*/psidev/psi/psi-ms/mzML/controlledVocabulary/psi-ms.obo"/>
<Cv fullName="UNIMOD" id="UNIMOD" uri="http://www.unimod.org/obo/unimod.obo"/>
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<DatasetSummary announceDate="2021-08-12" hostingRepository="MassIVE" title="Selective dephosphorylation by PP2A-B55 directs the meiosis I - meiosis II transition in oocytes">
<Description><![CDATA[Meiosis is a specialized cell cycle that requires sequential changes to the cell division machinery to facilitate changing functions. To define the mechanisms that enable the oocyte-to-embryo transition, we performed time-course proteomics in sea star oocytes from prophase I through the first embryonic cleavage. Although protein levels are broadly stable, dynamic waves of phosphorylation underlie each meiotic stage. We find that the phosphatase PP2A-B55 is reactivated at the Meiosis I/II transition resulting in the preferential dephosphorylation of threonine residues. Selective dephosphorylation is critical for directing the MI / MII transition as altering PP2A-B55 substrate preferences disrupts key cell cycle events after meiosis I. In addition, threonine to serine substitution of a conserved phosphorylation site in the substrate INCENP prevents its relocalization at anaphase I. Thus, through its inherent phospho-threonine preference, PP2A-B55 imposes specific phosphoregulated behaviors that distinguish the two meiotic divisions.]]></Description>
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<cvParam accession="MS:1001469" cvRef="MS" name="taxonomy: scientific name" value="Patiria miniata"/>
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<cvParam accession="MS:1000586" cvRef="MS" name="contact name" value="Mark Adamo"/>
<cvParam accession="MS:1000589" cvRef="MS" name="contact email" value="mark.e.adamo@dartmouth.edu"/>
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<cvParam accession="MS:1000586" cvRef="MS" name="contact name" value="Arminja Kettenbach"/>
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<cvParam accession="MS:1001925" cvRef="MS" name="submitter keyword" value="gamete"/>
<cvParam accession="MS:1001925" cvRef="MS" name="submitter keyword" value="meiosis"/>
<cvParam accession="MS:1001925" cvRef="MS" name="submitter keyword" value="oocyte"/>
<cvParam accession="MS:1001925" cvRef="MS" name="submitter keyword" value="prophase"/>
<cvParam accession="MS:1001925" cvRef="MS" name="submitter keyword" value="PP1"/>
<cvParam accession="MS:1001925" cvRef="MS" name="submitter keyword" value="PP2A"/>
<cvParam accession="MS:1001925" cvRef="MS" name="submitter keyword" value="PP2A-B55"/>
<cvParam accession="MS:1001925" cvRef="MS" name="submitter keyword" value="protein phosphatase"/>
<cvParam accession="MS:1001925" cvRef="MS" name="submitter keyword" value="phosphorylation"/>
<cvParam accession="MS:1001925" cvRef="MS" name="submitter keyword" value="dephosphorylation"/>
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