Updated publication reference for DOI(s): https://doi.org/10.1016/j.ocarto.2020.100099. An in vitro explant culture model of cartilage breakdown (post-traumatic osteoarthritis), where explant media mimics the synovial fluid. The OA model was induced by cytokine treatment with or without injury and potential therapeutic treatment was investigated by adding dexamethasone. Proteins released to culture media were analyzed by proteomics.