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PXD020447 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlePlasmodium PKG interacts with ICM1, a multi-pass membrane protein, in both asexual and sexual stages
DescriptionIn malaria parasites, all cGMP-dependent signalling is mediated through a single cGMP-dependent protein kinase (PKG). A major function of PKG is to control calcium signals essential for the parasite to exit red blood cells or for transmission to the mosquito vector. However, how PKG controls these signals in the absence of known second messenger-dependent calcium channels or scaffolding proteins remains a mystery. Here we identify a tightly-associated PKG partner protein in Plasmodium falciparum asexual blood stages. Named ICM1, the partner is a polytopic membrane protein with homology to transporters and calcium channels, raising the possibility of a direct functional link between PKG and calcium homeostasis
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSteven Howell
SpeciesList scientific name: Plasmodium falciparum 3D7; NCBI TaxID: 36329;
ModificationListiodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-07-20 02:57:03ID requested
12021-02-10 10:52:54announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: calcium homeostasis, cell signalling, Protein kinase G, Plasmodium falciparum, malaria, LC-MSMS, Orbitrap
Contact List
Bram Snijders
contact affiliationHead Of Proteomics STP, Francis Crick Institute, London
contact emailbram.snijders@crick.ac.uk
lab head
Steven Howell
contact affiliationFrancis Crick Institute
contact emailsteven.howell@crick.ac.uk
dataset submitter
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Dataset FTP location
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