PXD020447

PXD020447 is an original dataset announced via ProteomeXchange.

Title	Plasmodium PKG interacts with ICM1, a multi-pass membrane protein, in both asexual and sexual stages
Description	In malaria parasites, all cGMP-dependent signalling is mediated through a single cGMP-dependent protein kinase (PKG). A major function of PKG is to control calcium signals essential for the parasite to exit red blood cells or for transmission to the mosquito vector. However, how PKG controls these signals in the absence of known second messenger-dependent calcium channels or scaffolding proteins remains a mystery. Here we identify a tightly-associated PKG partner protein in Plasmodium falciparum asexual blood stages. Named ICM1, the partner is a polytopic membrane protein with homology to transporters and calcium channels, raising the possibility of a direct functional link between PKG and calcium homeostasis
HostingRepository	PRIDE
AnnounceDate	2021-02-10
AnnouncementXML	Submission_2021-02-10_10:52:54.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Steven Howell
SpeciesList	scientific name: Plasmodium falciparum 3D7; NCBI TaxID: 36329;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2020-07-20 02:57:03	ID requested
⏵ 1	2021-02-10 10:52:54	announced

Dataset with its publication pending

submitter keyword: calcium homeostasis, cell signalling, Protein kinase G, Plasmodium falciparum, malaria, LC-MSMS, Orbitrap

Bram Snijders
contact affiliation	Head Of Proteomics STP, Francis Crick Institute, London
contact email	bram.snijders@crick.ac.uk
lab head
Steven Howell
contact affiliation	Francis Crick Institute
contact email	steven.howell@crick.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/02/PXD020447

PRIDE project URI

• PRIDE
  1. PXD020447
     1. Label: PRIDE project
     2. Name: Plasmodium PKG interacts with ICM1, a multi-pass membrane protein, in both asexual and sexual stages