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PXD020351 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleBoth wnt signaling and epidermal stem cell-derived exosomes are involved in epidermal development
DescriptionMillions suffer from skin diseases. Functional epidermal stem cells are needed in skin therapy or drug screening in vitro. We obtained functional epidermal stem cells with intact stemness and cell junctions by treating them with wnt3a. Moreover, epidermal stem cell-derived exosomes were useful in epidermal development. Finally, functional epidermal 3D organoids with polarity were cultured using wnt3a and the supernatant derived from epidermal stem cells and fresh medium in a 1:1 ratio. These results provide novel directions for the improvement of skin organoids and their potential in clinical application.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJie Ma
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListmonohydroxylated residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-07-13 23:02:45ID requested
12022-11-22 00:56:16announced
Publication List
Leng L, Ma J, Lv L, Wang W, Gao D, Zhu Y, Wu Z, Both Wnt signaling and epidermal stem cell-derived extracellular vesicles are involved in epidermal cell growth. Stem Cell Res Ther, 11(1):415(2020) [pubmed]
Keyword List
submitter keyword: Epidermal stem cell, exosome, organoids, proteomics
Contact List
Ling Leng
contact affiliationTranslational Medicine Center, Peking Union Medical College Hospital.
contact emailzhenlinger@126.com
lab head
Jie Ma
contact affiliationNational Center for Protein Sciences (Beijing), Beijing Institute of Life Omics,
contact emailmajie729@163.com
dataset submitter
Full Dataset Link List
iProX dataset URI