PXD020351

PXD020351 is an original dataset announced via ProteomeXchange.

Title	Both wnt signaling and epidermal stem cell-derived exosomes are involved in epidermal development
Description	Millions suffer from skin diseases. Functional epidermal stem cells are needed in skin therapy or drug screening in vitro. We obtained functional epidermal stem cells with intact stemness and cell junctions by treating them with wnt3a. Moreover, epidermal stem cell-derived exosomes were useful in epidermal development. Finally, functional epidermal 3D organoids with polarity were cultured using wnt3a and the supernatant derived from epidermal stem cells and fresh medium in a 1:1 ratio. These results provide novel directions for the improvement of skin organoids and their potential in clinical application.
HostingRepository	iProX
AnnounceDate	2020-07-14
AnnouncementXML	Submission_2022-11-22_00:56:15.667.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jie Ma
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	monohydroxylated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2020-07-13 23:02:45	ID requested
⏵ 1	2022-11-22 00:56:16	announced

Leng L, Ma J, Lv L, Wang W, Gao D, Zhu Y, Wu Z, Both Wnt signaling and epidermal stem cell-derived extracellular vesicles are involved in epidermal cell growth. Stem Cell Res Ther, 11(1):415(2020) [pubmed]

submitter keyword: Epidermal stem cell, exosome, organoids, proteomics

Ling Leng
contact affiliation	Translational Medicine Center, Peking Union Medical College Hospital.
contact email	zhenlinger@126.com
lab head
Jie Ma
contact affiliation	National Center for Protein Sciences (Beijing), Beijing Institute of Life Omics,
contact email	majie729@163.com
dataset submitter

iProX dataset URI