Updated project metadata. This study describes altered CREB-dependent activity related transcription, and disrupted synaptic composition as common pathological features in ALS. These aberrations are restored by Apamin and XE991, two K+ channel blockers targeting the SK and Kv7 channels and modulating neuronal excitability.This study describes altered CREB-dependent activity related transcription, and disrupted synaptic composition as common pathological features in ALS. These aberrations are restored by Apamin and XE991, two K+ channel blockers targeting the SK and Kv7 channels and modulating neuronal excitability.