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PXD019729 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDifferential protein phosphorylation during stage conversion in Toxoplasma gondii
DescriptionThe intracellular parasite Toxoplasma gondii resides within a membrane bound parasitophorous vacuole and secretes an array of proteins to establish this replicative niche during acute stage of infection. When rapidly dividing tachyzoites convert to chronic stage bradyzoites, many secreted proteins are reported to dynamically redistribute as the cyst forms and secreted kinases are known to play a role in cyst formation. Using quantitative phosphoproteome and proteome analysis comparing tachyzoite and bradyzoite stages, we reveal widespread differential phosphorylation of secreted proteins. These data support a model in which secreted kinases and phosphatases are important to dynamically regulate parasite secreted proteins during stage conversion.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMalgorzata Broncel
SpeciesList scientific name: Toxoplasma gondii ME49; NCBI TaxID: 508771; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-06-11 17:30:28ID requested
12020-06-12 01:13:13announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: stage conversion, Toxoplasma, phosphorylation, tachyzoites, bradyzoites
Contact List
Moritz Treeck
contact affiliationSignalling in Apicomplexan Parasites Laboratory, The Francis Crick Institute, London NW1 1AT, UK
contact emailmoritz.treeck@crick.ac.uk
lab head
Malgorzata Broncel
contact affiliationThe Francis Crick Institute
contact emailmalgorzata.broncel@crick.ac.uk
dataset submitter
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Dataset FTP location
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