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PXD019187 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleEquine gluteal muscle LC-MSMS: Warmblood
DescriptionMyofibrillar myopathy (MFM) in horses is a late onset disease that affects performance and athleticism. It is characterized by myofibrillar disarray and protein aggregation with no known cause. The objective of this study was to elucidate the molecular drivers of MFM in Warmblood (WB) horses by proteomic profiling (5 MFM WB, 4 non-MFM WB) of gluteal muscle. MFM horses used in this study had a chronic history of poor performance and exercise intolerance as well as accumulation of desmin aggregates in > 4 myofibers per muscle sample. The Equine Neuromuscular Diagnostic Laboratory database at Michigan State University was queried to identify WB horses with snap frozen gluteus medius biopsies available for analysis. Non-MFM control horses were defined as horses with no history of exercise intolerance and no evidence of desmin accumulation or other histopathology in muscle biopsies. Muscle biopsy samples were obtained at rest from horses that had not undertaken strenuous exercise in the preceding 48 hours.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterStephanie Valberg
SpeciesList scientific name: Equus caballus (Horse); NCBI TaxID: 9796;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue; Ammonia-loss; methionine oxidation with neutral loss of 64 Da; TMT6plex; Dehydrated; Oxidation; Acetyl; N-acetylated residue; Carbamidomethyl; iodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-05-14 04:44:32ID requested
12021-09-09 00:36:28announced
Publication List
Williams ZJ, Velez-Irizarry D, Gardner K, Valberg SJ, Integrated proteomic and transcriptomic profiling identifies aberrant gene and protein expression in the sarcomere, mitochondrial complex I, and the extracellular matrix in Warmblood horses with myofibrillar myopathy. BMC Genomics, 22(1):438(2021) [pubmed]
Keyword List
submitter keyword: horse, gluteal muscle, LC-MSMS
Contact List
Stephanie Valberg
contact affiliationMary Anne McPhail Dressage Chair in Equine Sports Medicine Department Large Animal Clinical Sciences College of Veterinary Medicine Michigan State University
contact emailvalbergs@msu.edu
lab head
Stephanie Valberg
contact affiliationMichigan State University
contact emailvalbergs@msu.edu
dataset submitter
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Dataset FTP location
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