PXD019160
PXD019160 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Nucleosome binding by the pioneer transcription factor OCT4 |
| Description | The nucleosome is a fundamental unit of chromatin in eukaryotes, and generally prevents the binding of transcription factors to genomic DNA. Pioneer transcription factors overcome the nucleosome barrier, and bind their target DNA sequences in chromatin. OCT4 is a representative pioneer transcription factor that plays a role in stem cell pluripotency. In the present study, we biochemically analyzed the nucleosome binding by OCT4. Crosslinking mass spectrometry showed that OCT4 binds the nucleosome. |
| HostingRepository | jPOST |
| AnnounceDate | 2020-05-13 |
| AnnouncementXML | Submission_2022-09-18_03:46:59.016.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Lumi Negishi |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide; unknown modification |
| Instrument | LTQ Orbitrap Velos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2020-05-13 01:47:54 | ID requested | |
| 1 | 2020-05-13 01:59:11 | announced | |
| 2 | 2021-01-07 20:49:06 | announced | 2021-01-08: Updated PubMed. |
| 3 | 2021-02-04 17:08:06 | announced | 2021-02-04: Updated FTP location. |
| ⏵ 4 | 2022-09-18 03:46:59 | announced | 2022-09-18: Updated FTP location. |
Publication List
| Echigoya K, Koyama M, Negishi L, Takizawa Y, Mizukami Y, Shimabayashi H, Kuroda A, Kurumizaka H, Nucleosome binding by the pioneer transcription factor OCT4. Sci Rep, 10(1):11832(2020) [pubmed] |
Keyword List
| submitter keyword: nucleosome, chromatin, OCT4, Crosslinking MS |
Contact List
| Kurumizaka Hitoshi | |
|---|---|
| lab head | |
| Lumi Negishi | |
| contact affiliation | the University of Tokyo |
| dataset submitter | |
Full Dataset Link List
| jPOST dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST000844/ |
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