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PXD016845 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMS-based quantitative proteomic analysis of total proteomes from T. gondii strains upon MORC���s depletion and TgHDAC3 inhibition.
DescriptionT. gondii has a complex life cycle typified by an asexual development taking place in vertebrate, and a sexual reproduction which occurs exclusively in felids and thereby is less studied. The developmental transitions rely on changes in gene expression patterns, and recent studies have assigned roles for chromatin shapers, including histone modifications, in establishing specific epigenetic programs for each given stage. Here, we identified T. gondii microrchidia (MORC) protein as an upstream transcriptional repressor of sexual commitment. To explore the molecular role of MORC, we conducted mass spectrometry-based quantitative proteomic analyses to monitor the proteome changes upon MORC���s depletion and TgHDAC3 inhibition.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYohann Cout��
SpeciesList scientific name: Toxoplasma gondii; NCBI TaxID: 5811;
ModificationListmonohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-12-19 06:08:52ID requested
12020-01-09 11:37:17announced
22020-04-14 03:13:37announced2020-04-14: Updated publication reference for PubMed record(s): 32094587.
Publication List
Farhat DC, Swale C, Dard C, Cannella D, Ortet P, Barakat M, Sindikubwabo F, Belmudes L, De Bock PJ, Cout, é Y, Bougdour A, Hakimi MA, A MORC-driven transcriptional switch controls Toxoplasma developmental trajectories and sexual commitment. Nat Microbiol, 5(4):570-583(2020) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: Toxoplasma gondii, TGME49_305340, TgHDAC3, nanoLC-MS/MS
Contact List
Virginie Brun
contact affiliationEDyP
contact emailvirginie.brun@cea.fr
lab head
Yohann Cout��
contact affiliationEDyP
contact emailyohann.coute@cea.fr
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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