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PXD016713

PXD016713 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleChromatin bound O-GlcNAc proteins related to stress response and transcriptional regulation.
DescriptionO-GlcNAcylation performs a critical role in regulating stress response program and cellular homeostasis. However, systematic studies of O-GlcNAc regulated genotoxic stress-responsive transcriptional reprograming have been limited. The GalNAz metabolic labeled global chromatin-associated proteins were isolated from the cross-linked MCF-7 and MCF-7/ADR cells nucleus, and then modified by downstream click-chemistry. The de-crosslinked O-GlcNAz chromatin-bound proteins were enriched for label-free quantitative proteomics by LC-MS/MS.
HostingRepositoryiProX
AnnounceDate2020-08-30
AnnouncementXMLSubmission_2023-03-01_19:26:02.512.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitteryubo liu
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-12-11 23:48:52ID requested
12020-07-05 23:18:20announced
22023-03-01 19:26:03announced2023-03-02: Update publication information.
Publication List
Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J, Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response. Nat Commun, 11(1):5898(2020) [pubmed]
Keyword List
submitter keyword: O-GlcNAc´╝îmetabolic labeling´╝îproteomics
Contact List
yubo liu
contact affiliationDalian University of Technology
contact emailliuyubo@dlut.edu.cn
lab head
yubo liu
contact affiliationDalian University of Technology
contact emailliuyubo@dlut.edu.cn
dataset submitter
Full Dataset Link List
iProX dataset URI