Updated project metadata. Restoring the regenerative capacity of myocardium, which presents shortly in the newborns but lost in adulthood, is one of the therapeutic options for myocardial repair post various insults. In this work, we performed the phosphoproteomic analysis on neonatal regenerative myocardium and explored the Kinase-substrate network in neonatal myocardium to define potential signaling, which might be responsible for the transient regenerative capacity in the newborn mice.