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PXD014709 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlePharmacological induction of selective endoplasmic reticulum retention as a novel strategy for cancer therapy
DescriptionWe analysed the difference in the surface proteome of human cells that were either subjected to ER stress (induced by thapsigargin (Tg)) only or were additionally treated with a pharmacological inhibitor against the eIF2α kinase PERK, which is localized in the endoplasmic reticulum. Compared to single ER stress, several important plasma-membrane associated kinases, showed a significant downregulation under PERK inhibition.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterChristian Preisinger
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListbiotinylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-07-23 05:48:25ID requested
12020-03-02 05:48:23announced
22020-04-22 03:14:08announced2020-04-22: Updated publication reference for PubMed record(s): 32161259.
Publication List
Mahameed M, Boukeileh S, Obiedat A, Darawshi O, Dipta P, Rimon A, McLennan G, Fassler R, Reichmann D, Karni R, Preisinger C, Wilhelm T, Huber M, Tirosh B, Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy. Nat Commun, 11(1):1304(2020) [pubmed]
Keyword List
submitter keyword: human, LC-MS, plasma membrane
Contact List
Boaz Tirosh
contact affiliationThe School of Pharmacy The Hebrew University of Jerusalem POB 12065 Jerusalem 9112002, Israel
contact emailboazt@ekmd.huji.ac.il
lab head
Christian Preisinger
contact affiliationProteomics Facility, IZKF Aachen, University Clinic RWTH Aachen
contact emailcpreisinger@ukaachen.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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