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PXD014682 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSeasonally relevant changes in UV-A alter neurohormone levels and behavior via cOpsin1
DescriptionMany animals exhibit strong seasonal rhythms in their physiology and behavior, but the sensors conveying the environmental input are still unknown. In our study we provide detailed light measurements from the natural habitat of the marine bristle worm Platynereis dumerilii, showing that the ratios between different seasons differ more for day-time UV-A light than for longer wavelength. Mimicking seasonal UV-A differences, without photoperiodic changes, significantly decreased locomotor activities in non-mature worms and equaled the reduction occurring with short photoperiod. This UV-A dependent modulation of locomotion requires cOpsin1, likely signaled via Gi-signalling. cOpsin1 mutants also show a strong reduction of rate limiting enzymes for monogenic amine synthesis, as well as regulation of several neurohormones, including NPY, PDF and Vasotocin, as determined via parallel-reaction monitoring in this dataset. Together, these data provide strong functional evidence that cOpsin1 functions as a seasonal light receptor and suggest that daylengths, as well as UV-A levels signal annual time to animals.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterMarkus Hartl
SpeciesList scientific name: Platynereis dumerilii; NCBI TaxID: 6359;
ModificationListAmidated; Carbamidomethyl; Oxidation
InstrumentQ Exactive HF-X
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-07-19 10:11:57ID requested
12020-11-23 06:13:00announced
22022-08-29 16:52:25announced: Added PubMed Id
Publication List
Veedin Rajan VB, H, ä, fker NS, Arboleda E, Poehn B, Gossenreiter T, Gerrard E, Hofbauer M, M, ü, hlestein C, Bileck A, Gerner C, Ribera d'Alcala M, Buia MC, Hartl M, Lucas RJ, Tessmar-Raible K, Seasonal variation in UVA light drives hormonal and behavioural changes in a marine annelid via a ciliary opsin. Nat Ecol Evol, 5(2):204-218(2021) [pubmed]
Keyword List
submitter keyword: Targeted MS, PRM, quantification, neurohormones
Contact List
Kristin Tessmar-Raible
contact affiliationMax Perutz Labs, University of Vienna, Vienna Biocenter (VBC), Dr. Bohr-Gasse 9, Vienna, Austria
contact emailkristin.tessmar@mfpl.ac.at
lab head
Markus Hartl
contact affiliationMass Spectrometry Facility, Max Perutz Labs, Vienna Biocenter (VBC), Dr. Bohr-Gasse 3, Vienna, Austria
contact emailmarkus.hartl@univie.ac.at
dataset submitter
Full Dataset Link List
Panorama Public dataset URI