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PXD014427 is an original dataset announced via ProteomeXchange.

Dataset Summary
DescriptionPhase separation and reversible aggregation of proteins is a well-recognized adaptive strategy to survive stress. Here, we show that RCC subunits are engaged into improved super-quaternary organizations inside mitochondria during proteostasis stress. Assembly and oligomeric organizations of Complex II and V are consolidated while Complex I, III and IV are increasingly incorporated into respiratory supercomplexes in multiple cell-lines with different proteostasis and metabolic demands. Further, our results suggest that improved supra-organization of respiratory complexes (iSRC) is an outcome of conformational optimization towards better enzyme activity and co-terminus to appearance of aggregates of RCC subunits in stressed cells. Simultaneous reversion of iSRC and disappearance of aggregates during stress-withdrawal indicates complementarity between these quaternary and quinary proteome-reorganization mechanisms. iSRC appears to be the pre-emptive and deterministic ensemble over stochastic aggregation as it offers direct fitness-benefit.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSwasti Raychaudhuri
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-06-28 08:47:44ID requested
12020-09-18 01:30:22announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Mitochondria respiratory complex, supercomplex, proteostasis, proteotoxic stress, complexome profiling
Contact List
Dr. Swasti Raychaudhuri
contact affiliationCSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad - 500007, India
contact emailrcswasti@ccmb.res.in
lab head
Swasti Raychaudhuri
contact affiliationCSIR-Centre for Cellular and Molecular Biology
contact emailrcswasti@ccmb.res.in
dataset submitter
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Dataset FTP location
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