PXD013785 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Dynamic transcriptome-proteome correlation networks reveal human myeloid differentiation and neutrophil-specific programming |
Description | Human neutrophilic granulocytes form the largest pool of innate immune cells for host defense against bacterial and fungal pathogens. The dynamic changes that accompany the metamorphosis from a proliferating myeloid progenitor cell in the bone marrow into a mature non-dividing polymorphonuclear blood cell have remained poorly defined. Using mass spectrometry-based quantitative proteomics combined with transcriptomic data, we report on the dynamic changes of 5 developmental stages in the bone marrow and blood. Integration of transcriptomic and proteomic unveiled highly dynamic and differential interactions between RNA and protein kinetics during human neutrophil development which could be linked to functional maturation of typical end-stage blood neutrophil killing activities. |
HostingRepository | PRIDE |
AnnounceDate | 2019-11-07 |
AnnouncementXML | Submission_2020-09-28_00:22:45.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Maartje van den Biggelaar |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion ETD |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-05-09 06:27:30 | ID requested | |
1 | 2019-11-07 08:05:08 | announced | |
⏵ 2 | 2020-09-28 00:22:46 | announced | 2020-09-28: Updated publication reference for PubMed record(s): 31747616. |
Publication List
Hoogendijk AJ, Pourfarzad F, Aarts CEM, Tool ATJ, Hiemstra IH, Grassi L, Frontini M, Meijer AB, van den Biggelaar M, Kuijpers TW, Dynamic Transcriptome-Proteome Correlation Networks Reveal Human Myeloid Differentiation and Neutrophil-Specific Programming. Cell Rep, 29(8):2505-2519.e4(2019) [pubmed] |
Keyword List
submitter keyword: Proteomics,Transcriptomics, neutriphils, myeloid differentiation |
Contact List
M. van den Biggelaar |
contact affiliation | Department of Molecular and Cellular Hemostasis, Sanquin Research Amsterdam, NL |
contact email | m.vandenbiggelaar@sanquin.nl |
lab head | |
Maartje van den Biggelaar |
contact affiliation | Sanquin Research |
contact email | m.vandenbiggelaar@sanquin.nl |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/11/PXD013785 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD013785
- Label: PRIDE project
- Name: Dynamic transcriptome-proteome correlation networks reveal human myeloid differentiation and neutrophil-specific programming