Update publication information. Acute aortic dissection (AAD) is a catastrophic cardiovascular disease with high disability and mortality due to multiple fatal complications. However, the molecular changes of serum proteome after AAD are not very clear. Here, we performed isobaric tags for relative and absolute quantitation (iTRAQ) based comparative proteomic analysis to investigate the proteome profile changes after AAD by collecting serum samples from 20 AAD patients and 20 controls.