PXD013231 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Analysis of 1,508 plasma samples of the DiOGenes study - Robust, single shot capillary flow data-independent acquisition to decipher proteomic profiles of weight loss and maintenance |
Description | Based on our own experience and the evaluation of recent large-scale plasma mass spectrometry (MS) based proteomic studies (1, 2), we identified two outstanding challenges: slow and delicate nano-flow liquid chromatography (LC) and irreproducibility of identification of data-dependent acquisition (DDA). We determined a optimal solution reducing these limitations with robust capillary-flow data-independent acquisition (DIA) MS. This platform is capable of measuring 31 plasma proteomes per day. Using this setup, we acquired a large-scale plasma study of the diet, obesity and genes dietary (DiOGenes) comprising 1,508 samples. |
HostingRepository | PRIDE |
AnnounceDate | 2019-04-06 |
AnnouncementXML | Submission_2019-04-06_00:30:09.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Roland Bruderer |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; iodoacetamide derivatized residue |
Instrument | TripleTOF 5600; Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-03-26 00:46:29 | ID requested | |
⏵ 1 | 2019-04-06 00:30:10 | announced | |
2 | 2019-04-11 00:31:11 | announced | Updated project metadata. |
3 | 2019-05-14 07:22:35 | announced | Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
curator keyword: Biological |
submitter keyword: plasma proteomics, data-independent acquisition, SWATH, label-free quantification, stable isotope-based quantification, library, single shot, high throughput, clinical proteomics |
Contact List
Lukas Reiter |
contact affiliation | Biognosys AG, Schlieren, Schweiz |
contact email | lukas.reiter@biognosys.ch |
lab head | |
Roland Bruderer |
contact affiliation | Biognosys AG |
contact email | roland.bruderer@biognosys.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/04/PXD013231 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD013231
- Label: PRIDE project
- Name: Analysis of 1,508 plasma samples of the DiOGenes study - Robust, single shot capillary flow data-independent acquisition to decipher proteomic profiles of weight loss and maintenance