PXD011929-1

PXD011929 is an original dataset announced via ProteomeXchange.

Title	Meltome Atlas - thermal proteome stability across the tree of life
Description	We have developed a mass spectrometry-based approach that allowed us to quantitatively monitor protein stability across a broad range of temperatures at the proteome scale (meltome). We profiled the meltomes of several microorganisms and eukaryotic species including human, allowing to investigate the determinants of protein thermostability and survival in various environmental niches. Moreover, we will make Meltome Atlas a valuable, publicly available resource for the biological community to investigate their proteins of interest in the context of protein thermostbility.
HostingRepository	PRIDE
AnnounceDate	2020-04-29
AnnouncementXML	Submission_2020-04-29_00:34:00.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Anna Jarzab
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Arabidopsis thaliana (Mouse-ear cress); NCBI TaxID: 3702; scientific name: Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579); NCBI TaxID: 300852; scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932; scientific name: Picrophilus torridus; NCBI TaxID: 82076; scientific name: Geobacillus stearothermophilus; NCBI TaxID: 391290; scientific name: Escherichia coli; NCBI TaxID: 562; scientific name: Caenorhabditis elegans; NCBI TaxID: 6239; scientific name: Bacillus subtilis; NCBI TaxID: 1423; scientific name: Oleispira antarctica; NCBI TaxID: 188908; scientific name: Homo sapiens (Human); NCBI TaxID: 9606; scientific name: Danio rerio (Zebrafish) (Brachydanio rerio); NCBI TaxID: 7955; scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: 7227;
ModificationList	methionine oxidation with neutral loss of 64 Da; acetylated residue
Instrument	Orbitrap Fusion Lumos; iTRAQ reagent 116

Revision	Datetime	Status	ChangeLog Entry
0	2018-12-03 23:15:23	ID requested
⏵ 1	2020-04-29 00:34:02	announced

Jarzab A, Kurzawa N, Hopf T, Moerch M, Zecha J, Leijten N, Bian Y, Musiol E, Maschberger M, Stoehr G, Becher I, Daly C, Samaras P, Mergner J, Spanier B, Angelov A, Werner T, Bantscheff M, Wilhelm M, Klingenspor M, Lemeer S, Liebl W, Hahne H, Savitski MM, Kuster B, Meltome atlas-thermal proteome stability across the tree of life. Nat Methods, 17(5):495-503(2020) [pubmed]

curator keyword: Technical, Biological

submitter keyword: Meltome Atlas, melting point, thermostability, Thermal Proteome Profiling, protein stability

Bernhard Kuster
contact affiliation	Technical University of Munich
contact email	kuster@tum.de
lab head
Anna Jarzab
contact affiliation	Technical University of Munich
contact email	anna.jarzab@tum.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/04/PXD011929

PRIDE project URI

• PRIDE
  1. PXD011929
     1. Label: PRIDE project
     2. Name: Meltome Atlas - thermal proteome stability across the tree of life