PXD010277

PXD010277 is an original dataset announced via ProteomeXchange.

Title	Design and synthesis of tailored human caseinolytic protease P inhibitors
Description	Human caseinolytic protease P (hClpP) is important for degradation of misfolded proteins in the mitochondrial unfolded protein response. We here introduce tailored hClpP inhibitors that utilize a steric discrimination in their core naphthofuran scaffold to selectively address the human enzyme. This novel inhibitor generation exhibited superior activity compared to previously introduced beta-lactones, optimized for bacterial ClpP. Further insights into the bioactivity and binding to cellular targets were obtained via chemical proteomics as well as proliferation- and migration studies in cancer cells.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:46:13.575.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Thomas Gronauer
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-06-29 08:59:59	ID requested
1	2019-03-05 00:47:58	announced
⏵ 2	2024-10-22 04:46:19	announced	2024-10-22: Updated project metadata.

Gronauer TF, Mandl MM, Lakemeyer M, Hackl MW, Me, ß, ner M, Korotkov VS, Pachmayr J, Sieber SA, Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb), 54(70):9833-9836(2018) [pubmed]

10.1039/c8cc05265d;

curator keyword: Biomedical

submitter keyword: Mitochondria, Jurkat,ClpP, Huh7, phenyl esters

Stephan Axel Sieber
contact affiliation	TU Munich, Department of Chemistry Lichtenbergstr. 4 Garching, DE 85747
contact email	stephan.sieber@tum.de
lab head
Thomas Gronauer
contact affiliation	TU Munich Department of Chemistry Chair of Organic Chemistry 2 Lichtenbergstraße 4 85748 Garching Germany
contact email	thomas.gronauer@tum.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/03/PXD010277

PRIDE project URI

• PRIDE
  1. PXD010277
     1. Label: PRIDE project
     2. Name: Design and synthesis of tailored human caseinolytic protease P inhibitors