PXD010174-3
PXD010174 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | An Outer Membrane Protein-Targeting Antibiotic Against Resistant Gram-Negative Bacterial Pathogens |
Description | There is an urgent need for novel antibiotics against carbapenem and 3rd generation cephalosporin-resistant Gram-negative pathogens, for which the last-resort antibiotics have lost most of their efficacy. We describe here a novel class of synthetic antibiotics that was inspired from natural product-derived scaffolds. The antibiotics have an unprecedented mechanism of action, which targets the main component (BamA) of the Bam folding machinery required for folding and insertion of ß-barrel proteins into the outer membrane of Gram-negative bacteria. This OMPTA (outer membrane protein-targeting antibiotic) class shows potent activity against multidrug-resistant Gram-negative ESKAPE pathogens and overcomes colistin-resistance both in vitro and in vivo. A clinical candidate has the potential to address life threatening Gram-negative infections with high unmet medical need. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:57:43.824.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Maik Müller |
SpeciesList | scientific name: Escherichia coli; NCBI TaxID: 562; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2018-06-21 01:53:50 | ID requested | |
1 | 2019-10-21 22:27:20 | announced | |
2 | 2020-01-02 06:32:04 | announced | 2020-01-02: Updated publication reference for PubMed record(s): 31645764. |
⏵ 3 | 2024-10-22 04:57:51 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1038/s41586-019-1665-6; |
Luther A, Urfer M, Zahn M, M, ü, ller M, Wang SY, Mondal M, Vitale A, Hartmann JB, Sharpe T, Monte FL, Kocherla H, Cline E, Pessi G, Rath P, Modaresi SM, Chiquet P, Stiegeler S, Verbree C, Remus T, Schmitt M, Kolopp C, Westwood MA, Desjonqu, è, res N, Brabet E, Hell S, LePoupon K, Vermeulen A, Jaisson R, Rithi, é V, Upert G, Lederer A, Zbinden P, Wach A, Moehle K, Zerbe K, Locher HH, Bernardini F, Dale GE, Eberl L, Wollscheid B, Hiller S, Robinson JA, Obrecht D, Chimeric peptidomimetic antibiotics against Gram-negative bacteria. Nature, 576(7787):452-458(2019) [pubmed] |
Keyword List
curator keyword: Biological, Biomedical |
submitter keyword: macrocyclic peptidomimetic antibiotics, novel molecular mode of action, Lpt complex, E.coli, DDA, OMPTA (outer membrane-targeting antibiotics), LC-MS/MS, Bam complex, photoaffinity labeling, Thermo Q-Exactive Plus, interaction mapping, photo crosslinking,Gram-negative ESKAPE pathogens |
Contact List
Bernd Wollscheid | |
---|---|
contact affiliation | Institute of Molecular Systems Biology & Department of Health Sciences and Technology, ETH Zurich, Switzerland |
contact email | bernd.wollscheid@hest.ethz.ch |
lab head | |
Maik Müller | |
contact affiliation | ETH Zurich |
contact email | maimuell@ethz.ch |
dataset submitter |
Full Dataset Link List
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/10/PXD010174 |
PRIDE project URI |
Repository Record List
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