Updated project metadata.
Cardiovascular diseases represent a leading cause of
deaths globally; of which atherosclerosis is a major contributor.
Selective retention of circulating apolipoprotein B particles in the sub
endothelial space by arterial wall proteoglycans and their subsequent
modification is currently thought to be a hallmark of the disease. The
exact mechanism responsible for lesion development is not fully
understood. Currently, ultrasonic assessment of carotid artery intima
media thickness (IMT) is commonly used as a pre-clinical marker of
atherosclerosis. However, as the onset of atherosclerotic process and
the appearance of carotid artery plaque can vary, the identification of
additional biomarkers showing potential etiological aspects of disease
is an important goal. This study describes the use of a label free mass
spectrometry approach in the proteomics analysis of serum samples from
control and atherosclerotic subjects. The samples were from a study
cohort recruited in The Cardiovascular Risk in Young Finns Study, with a
goal of identifying biomarkers for atherosclerosis. Samples from 43
individuals with a early non-obstructive plaques and 43 controls were
used (Matched by age, sex, body size and systolic blood pressure).