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PXD008166 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleA comprehensive proteome-wide lysine crotonylation profiling of papaya (Carica papaya L.)
DescriptionLysine crotonylation of histone proteins is a recently-identified post-translational modification with multiple cellular functions. However, lysine crotonylation of non-histone proteins in fruit cells has not yet been studied. Using high-resolution LC-MS/MS coupled with highly sensitive immune-affinity antibody analysis, a global crotonylation proteome analysis of papaya (Carica papaya L.) fruit was performed. In total, 2,120 proteins with 5,995 lysine crotonylation sites were discovered, among which eight conserved motifs were identified. Bioinformatic analysis linked crotonylated proteins to multiple metabolic pathways, including biosynthesis of antibiotics, carbon metabolism, biosynthesis of amino acids, and glycolysis. Notably, 40 crotonylated enzymes involved in various amino acid metabolism pathways were identified, suggesting a potential conserved function for crotonylation in the regulation of amino acid metabolism. Numerous crotonylation sites were identified in proteins involved in hormone signaling and cell wall-related pathways, indicating a role for crotonylation in the regulation of fruit ripening in papaya. Our comprehensive crotonylation proteome indicates diverse functions for lysine crotonylation in fruit ripening-related proteins.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterzhang zhang
SpeciesList scientific name: Carica papaya; NCBI TaxID: 3649;
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-11-08 02:18:29ID requested
12017-12-18 01:08:08announced
22019-03-07 05:38:50announcedUpdated publication reference for PubMed record(s): 29844531.
Publication List
Liu K, Yuan C, Li H, Chen K, Lu L, Shen C, Zheng X, A qualitative proteome-wide lysine crotonylation profiling of papaya (Carica papaya L.). Sci Rep, 8(1):8230(2018) [pubmed]
Keyword List
curator keyword: Biological
submitter keyword: Amino acid metabolism
cell wall
fruit ripening
Contact List
Kaidong Liu
contact affiliationLife Science and Technology School, Lingnan Normal University, Zhanjiang, Guangdong 524048, PR China
contact emailliukaidong2001@126.com
lab head
zhang zhang
contact affiliationPTM
contact emailzhang_zhang@ptm-biolab.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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